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KMID : 0352720100340030227
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Journal of Ginseng Research
2010 Volume.34 No. 3 p.227 ~ p.236
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Cosmetic Potential of Enzymatic Treated Ginseng Leaf
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Lee Hyun-Sun
Lee Hyun-jung
Cho Hye-Jin
Park Sung-Sun
Kim Jin-Man
Suh Hyung-Joo
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Abstract
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The objective of this study was to evaluate the potential use of ginseng leaf as a cosmetic material. In this research, we employed enzymatic treated ginseng leaf by using Ultraflo L to improve the recovery of ginsenosides from the ginseng leaf and studied the biological activities and skin safety of the enzymatic treated ginseng leaf for use as a cosmetic material. The total ginsenoside contents of the non-enzymatic treated ginseng leaf (NEGL) and Ultraflo L treated ginseng leaf (UTGL) were 271 and 406 ㎎/g, respectively. The level of metabolite ginsenosides (sum of Rg2, Rg3, Rg5, Rk1, compound K, Rh1, Rh2, and F2) was higher in UTGL (93.1 ㎎) compared to NEGL (62.4 ㎎) in one gram ginseng leaf extract. The increase in amounts of ginsenoside types in UTGL compared to NEGL was generally 140% to 157%. UTGL exhibited relatively higher 2,2-diphenyl-2-picrylhydrazyl hydrate (IC??, 2.8 ㎎/mL) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (IC??, 1.6 ㎎/mL) radical scavenging activities compared to NEGL (4.8 ㎎/mL and 2.2 ㎎/mL). The UTGL group showed normalized hydrogen peroxide, lipid peroxidation and visual wrinkling grade induced-UVB exposure. The UTGL did not induce any adverse reactions such as erythema and edema on intact skin sites; however, some guinea pigs treated with UTGL on abraded skin sites showed very slight erythema. The primary irritation index (PII) score of UTGL was 0.05 and it was classified as a practically non-irritating material (PII, 0 to 0.5). In skin sensitization tests with guinea pigs, UTGL had a positive rate of skin sensitization at 40%, and the mean evaluation score was 0.4.
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KEYWORD
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Panax ginseng leaves, Enzymatic treatment, Ultraflo L, Cosmeceutical
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